Participants got either psilocybin or nicotine patches, plus 13 weeks of therapy.
By the six-month mark, 17 people in the mushroom group stayed smoke-free, while only four managed it with patches.
Earlier studies showed even longer-term success with psilocybin.
Since most quit-smoking medications help fewer than a third of people, these results are pretty promising.
More trials are on the way to see how psychedelics could change addiction treatment for good.
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